Product Description
Tocopherol Succinate (CAS No. 4345-03-3) is a potent antioxidant with notable biological activity. Studies have shown that it may provide protective effects against gamma radiation by stimulating the production of granulocyte colony-stimulating factor (G-CSF). It has also demonstrated potential in inducing apoptosis in human gastric cancer and neuroblastoma cells, while inhibiting the proliferation of mesothelioma cells through the down-regulation of fibroblast growth factor receptor-1 (FGFR-1).
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Chemical Properties
| Melting point | ~76 °C(lit.) |
| Boiling point | 625.8±55.0 °C(Predicted) |
| Density | 1.002±0.06 g/cm3(Predicted) |
| Vapor pressure | 0Pa at 20℃ |
| Storage temp | -20°C |
| Solubility | Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol. |
| Form | Solid |
| Pka | 4.35±0.17(Predicted) |
| Color | White or off-white |
| Odor | Little or no odor |
| Biological source | synthetic |
| λmax | 286nm(EtOH)(lit.) |
| Merck | 14,9495 |
| BRN | 4038233 |
| Specific Activity | 1210IU/g |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| LogP | 12 at 25℃ |
| CAS DataBase Reference | 4345-03-3(CAS DataBase Reference) |
| EPA Substance Registry System | D-.alpha.-Tocopheryl acid succinate (4345-03-3) |
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Product Application
It is a potent and novel antineoplastic compound with high selectivity and exhibits synergistic activity with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL/Apo2 ligand). It has been reported to inhibit the proliferation of mesothelioma cells by selectively down-regulating fibroblast growth factor receptors and may enhance the antitumor activity of dendritic cell-based vaccines.
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