Product Description of Polyethylene-polypropylene glycol CAS#9003-11-6
Pluronic® F-127 is a nonionic surfactant commonly used to dissolve hydrophobic compounds, such as AM ester calcium indicators and fluorescent probes, and improve their cellular uptake.
It is available as a ready-to-use 10% aqueous solution, simplifying laboratory preparation. It is mainly used to assist in loading fluorescent dyes and indicators into cells, with conditions adjusted according to the cell type and compound.
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Polyethylene-polypropylene glycol CAS#9003-11-6 Chemical Properties
| Melting point | 57-61 °C |
| Boiling point | >200 °C(lit.) |
| bulk density | 1050kg/m3 |
| density | 1.095 g/mL at 25 °C |
| vapor density | >1 (vs air) |
| vapor pressure | <0.3 mm Hg ( 20 °C) |
| refractive index | n20/D 1.466 |
| Fp | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: at <70 °Csoluble |
| form | solution |
| color | APHA: ≤120, 50/50 in CH3OH |
| PH | 5.0-7.5 (100g/L in H2O) |
| PH Range | 5.0 - 7.5 |
| biological source | synthetic |
| Water Solubility | Miscible with water. |
| λmax | λ: 260 nm Amax: ≤0.3 |
| λ: 280 nm Amax: ≤0..2 | |
| Merck | 137644 |
| Hydrophilic-Lipophilic Balance (HLB) | 18 - 23 |
Cosmetics Ingredients Functions | SURFACTANT - CLEANSING |
| SURFACTANT - HYDROTROPE | |
| CLEANSING | |
| SOLVENT | |
| HUMECTANT | |
| EMULSION STABILISING | |
| BINDING | |
| SURFACTANT - EMULSIFYING | |
| VISCOSITY CONTROLLING | |
| InChI | 1S/C3H6O.C2H4O/c1-3-2-4-3;1-2-3-1/h3H,2H2,1H3;1-2H2 |
| InChIKey | RVGRUAULSDPKGF-UHFFFAOYSA-N |
| SMILES | O2C(C2)C.O1CC1 |
| LogP | -1.293 (est) |
| EPA Substance Registry System | Poloxalene (9003-11-6) |
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Product Application of Polyethylene-polypropylene glycol CAS#9003-11-6
Polyethylene-polypropylene glycol is a nonionic polyoxyethylene–polyoxypropylene copolymer widely used in pharmaceuticals as an emulsifier, solubilizer, and surfactant. Its hydrophilic and hydrophobic segments provide good surface activity.
Different grades vary in the ethylene oxide/propylene oxide ratio, giving them different properties. It is commonly used in intravenous fat emulsions, syrups, elixirs, ointments, suppositories, gels, and tablets as a solubilizer, stabilizer, wetting agent, binder, or coating material.
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